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Species: |
Rat |
Strain/breeder: |
Crl:Wist Han |
Sex: |
Male |
Age: |
15 Weeks |
Study type: |
26-Week oral toxicity study |
Treatment: |
VEGF-receptor tyrosine kinase inhibitor |
Animal status: |
Sacrifice before schedule after 7 weeks |
Clinical findings: |
White discoloration and fracture of teeth |
Organ(s): |
Teeth (incisors) and bone (femur/tibia) |
Macroscopic finding(s): |
White discoloration and fracture of teeth |
Staining: |
H&E |
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Fig. 1 (128k)
Fig. 2 (130k)
Fig. 3 (94k)
Fig. 4 (126k)
Fig. 5 (118k)
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