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• Toxicologic pathologists at (bio) pharmaceutical / biotechnology / chemical industry in Germany, France, Switzerland, UK, Denmark, Netherlands, Italy, Belgium, Finland, Sweden, Czech Republic, Hungary, Portugal, Romania, Spain…

• We are an integral part of medical research and safety evaluation by interpreting efficacy and safety studies based on internationally approved study designs by e.g. EPA, FDA, JMAFF, OECD, including stringent requirements on animal welfare. One example is the current European initiative REACH to identify and address data gaps in toxicological knowledge about every chemical currently on the market in Europe
• We are contributing to preclinical regulatory and early research studies:
  • determining efficacy endpoints and mode of action
  • identification of target organs/ -tissues in early phase drug candidates
  • safety assessment of promising drug candidates and chemicals

• 60% of the toxicologic pathologists in Europe will retire within the next 15 years
• 40% will retire within the next 10 years

• Working in a team
• International environment
• Compatibility of family and career (e.g. home office, flexible working time, reduction of working hours)
• Competitive salary
• Professional and personal development
• Continuing education

• Scientific evaluation and interpretation of histopathological pathology data within drug development, investigative / mechanistic toxicity studies, carcinogenicity studies
  • Species: rat, mouse, dog, rabbit, minipig, non-human primate, fish
  • Samples: broad organ spectrum (approx. 45 tissues per animal)
  • Questions: target organs, pathogenesis, dose dependency, toxicologic relevance of findings
  • Assay: semi-quantitative (grading) diagnostic using standard HE slides, image analysis, special stains, immunohistochemistry, in-situ hybridization
  • Approach:
    • Comparative slide reading of treatment groups vs. control group
    • Mostly organ/tissue based
• Writing reports that will be used for the registration process with various regulatory bodies
• Performing pathology peer reviews (evaluation of reports from external partners)
• Understanding, reviewing and reporting clinical pathology data
• Author scientific manuscripts and give presentations
• Providing scientific contribution to a broad range of activities in teams from early discovery through late stage development including project management
• Responsibility for technical quality, resource planning, project deadlines and follow-up of costs
• Attend scientific meetings and continuing education seminars
• Working under "Good laboratory practices" (GLP) conditions means
  • All procedures are described in detail in standard operating procedures (SOP)
  • All activities are guided by a study protocol
  • Documentation of all procedures
  • Qualification of personnel
  • Archiving of raw data
  • Audits by internal quality management
  • Audits / inspections by authorities

• Pathology (necropsy, histopathology)
• Toxicologic and pharmacologic pathology
• Basic toxicology, laboratory animal science and animal welfare
• Clinical pathology
• Written and verbal presentation of pathology data
• Scientific and technical expertise in immunohistochemistry, in-situ hybridization and new technologies including molecular biology ("-omics")
• Digital pathology (slide sharing, annotation, machine learning, image analysis)
• Proficiency in written and spoken English

• University degree in veterinary / human medicine or equivalent
• Postgraduate scientific degree (ideally in the field of pathology): Dr. med. vet. / PhD
• Specialization in pathology / toxicology include
  • National (postgraduate) certificate in (veterinary) pathology e.g. in France, UK, Germany, The Netherlands and other countries
  • International postgraduate qualification in pathology
    • Diplomate ECVP see http://www.ecvpath.org/residency-training/
    • Diplomate ACVP see http://www.acvp.org/?page=Training_Programs

• Available training options (selection)
  • Residency training ECVP (Diplomate ECVP) see http://www.ecvpath.org/residency-training/
  • ECVP/ESVP Summer School in Veterinary Pathology see http://www.ecvpath.org/summerschool/
  • Residency training ACVP (Diplomate ACVP) see http://www.acvp.org/?page=Training_Programs
  • Continuing Education Symposiums (CES) of the British Society of Toxicological Pathology (BSTP) see http://www.bstp.org.uk/events/categories/ces/
  • Several course incl. General and laboratory animal pathology, Faculty of Health and Medical Sciences, Copenhagen, DK see https://phdcourses.ku.dk/Kursusliste.aspx?TermId=340&KatId=53&OCatID=4300119&sitepath=SUND
• Recommended journals
  • Toxicologic Pathology see http://journals.sagepub.com/home/tpx
  • Veterinary Pathology see http://journals.sagepub.com/home/vet
  • Journal of Toxicologic Pathology see https://www.jstage.jst.go.jp/browse/tox/
• Attending meetings and congresses see Calendar

Certifications recognized experts in Toxicologic Pathology:

• International registration / qualification in toxicology or laboratory animal medicine
  • Diplomate of the American Board of Toxicology (ABT) see http://www.abtox.org/AboutABT.aspx
  • Registered in the European Register of Toxicologists (ERT) see http://www.eurotox.com/ert/
  • Fellow International Academy of Toxicologic Pathology (IATP) see http://www.iatpfellow.org/
  • Diplomates European College of Laboratory Animal Medicine (ECLAM) see http://eslav-eclam.org/education/continuing-education-and-specialisation/

• Finding a new position relies on the networking and the personal contact between employers and candidates - involvement of professional recruiters and internet platforms are far less important
• Just curious? Any questions? Please don't hesitate to contact us. The Councillor for Residents and Early Career Pathologists is looking forward to answering your questions and provide you with personal contacts for discussions, informal visits and practical times.