European Society of Toxicologic Pathology
ESTP Congress 2004: Case No 4
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| Digital slide: |
Case 4 |
| Species: |
Rat |
| Strain/breeder: |
|
| Sex: |
|
| Age: |
Approx. 20 weeks |
| Study type: |
13-week gavage study |
| Treatment: |
Triaminopyrimidine |
| Animal status: |
|
| Clinical findings: |
No differences in survival, clinical findings, body weight and food intake compared to control animals
Hematology:
· slightly decreased erythrocyte count and haemoglobin
· slightly increased MCV (males), MCH (females) and relative reticulocyte count (females)
Clinical Biochemistry:
· slightly increased glucose and urea (females) and calcium and phosphorous (males) concentration
· slightly increased a1-globulin fraction and decreased ?-globulin fraction (absolute/relative) in males (electrophoresis)
Urinalysis:
· increased volume with slightly increased pH-value (both sexes) and increased glucose (males)
· light to red brown discoloration |
| Organ(s): |
Kidneys (Compounds A or B) |
Gross
finding(s): |
Organ Weights:
· increased absolute and relative kidney weight
Macroscopic Lesions:
· no differences to controls |
| Staining: |
H&E |
| Literature: |
|
|
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