 | |
| Digital slide(s): |
Case 8a
Case 8b
Case 8c
Case 8d |
| Species / breed: |
Rat, Sprague Dawley |
| Sex: |
Male |
| Age: |
Approx. 6 weeks at start of the study |
| Study type: |
Mechanistic 2-week oral gavage toxicity study |
| Treatment: |
Compound X in early development |
| Clinical findings: |
Dyspnea, audible respiration, excessive salivation and reflux on day 7 and 8 of dosing; preterminal euthanasia on day 8 due to moribund condition |
| Organ(s): |
Nasal Cavity (level II and level III) and Nasopharynx (4 levels) |
| Gross finding(s): |
– |
| Staining: |
H&E |
