ESTP Congress 2009: Case No 8


Digital slide(s):	Case 8a Case 8b Case 8c Case 8d
Species / breed:	Rat, Sprague Dawley
Sex:	Male
Age:	Approx. 6 weeks at start of the study
Study type:	Mechanistic 2-week oral gavage toxicity study
Treatment:	Compound X in early development
Clinical findings:	Dyspnea, audible respiration, excessive salivation and reflux on day 7 and 8 of dosing; preterminal euthanasia on day 8 due to moribund condition
Organ(s):	Nasal Cavity (level II and level III) and Nasopharynx (4 levels)
Gross finding(s):	–
Staining:	H&E